Convergent evidence suggests that the perirhinal cortex (PRC) is involved in perception, in addition to long-term memory, by representing higher-order object feature conjunctions. Recent functional magnetic resonance imaging (fMRI) investigations have shown greater PRC activity during the processing of objects with a higher versus lower degree of features in common, but notably, these studies have been limited to examining only two levels of feature overlap. To address this, we scanned neurologically healthy participants with fMRI during a 1-back working memory task for objects that possessed a very low, low, medium or high degree of feature overlap. Somewhat consistent with previous findings, trends towards greater PRC activity for high versus medium feature overlap objects, and for semantically identical compared to semantically different objects were observed. However, other aspects of our data, including diminished PRC activity during medium versus low feature overlap objects, are difficult to interpret and require further investigation.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/33401 |
| Date | 21 November 2012 |
| Creators | Douglas, Danielle |
| Contributors | Lee, Andy, Barense, Morgan |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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