The Fibronectin leucine-rich transmembrane (Flrt) gene family has been implicated in
FGF signaling, which is crucial for coordinating craniofacial morphogenesis and epithelial mesenchymal interactions (EMI). The gene expression patterns of Flrt1, Flrt2 and Flrt3 were analyzed during critical stages of murine midfacial development from 9.5-15.5 dpc. Flrt2 and Flrt3 were observed to have unique expression patterns in the midface, whereas Flrt1 did not. From 10.5-12.5dpc, Flrt2 was expressed in the mesenchyme of the medial nasal process(MNP). Flrt3 was expressed in the mesenchyme of the lateral nasal process (LNP) and MNP. From 13.5-15.5dpc, Flrt2 was expressed in the oral ectomesenchyme of the palatal shelves, whereas Flrt3 was expressed in the medial edge and oral epithelium. Both Flrt2 and Flrt3 were expressed in different sites of the developing tooth buds and hair follicles. This suggests that Flrt2 and Flrt3
have unique roles during craniofacial morphogenesis, whereas Flrt1 may have a more
generalized role.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/18261 |
| Date | 13 January 2010 |
| Creators | Chung, Karen Clare |
| Contributors | Peel, Sean, Gong, Siew-Ging |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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