Calcium polyphosphate (CPP) is a suitable substrate in a novel tissue-engineering strategy. The strategy aims to culture articular cartilage in vitro onto porous CPP and then implant the biphasic construct into the joint to replace damaged cartilage. CPP substrates should degrade faster to enhance repair. This project examined the structural and degradation effects of doping CPP with sodium
phosphate, sodium hydroxide, and sodium carbonate. Doping concentration was narrowed to 0.01 Na2O/CaO for comparable phase composition to pure CPP. All doped groups sintered and crystallized at lower temperatures than pure CPP. Hydroxide-doped CPP did not form adequate sinter necks. At similar open porosity, Phosphate-doped CPP had similar diametral strength than pure CPP, while Carbonate-doped CPP had greater diametral strength. Degradation in vitro
showed that Phosphate-doped CPP had greater strength loss, while Carbonate-doped CPP had
similar strength loss, compared to pure CPP. Both doped groups degraded more slowly than pure CPP.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/18945 |
| Date | 16 February 2010 |
| Creators | Ue, Judy Wai-Tak |
| Contributors | Coyle, Thomas W., Grynpas, Marc D. |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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