A versatile method for the preparation of 2-amino-2-deoxy-, 3-amino-3-deoxy-, 4- amino-4-deoxy-, and 5-amino-5-deoxy-sugars from noncarbohydrate precursors, halobenzenes 1 (Figure 1), has been developed.
See: Figure 1: Aminosugar Targets from Halobenzenes
This methodology has also been applied to achieve the synthesis of protected D-mannose- 2,3,4,5,6-d₅ 191, and derivatives thereof, from the metabolite d₅- bromocyclohexadiene-cis-diol 189 obtained from the microbial oxidation of d₅- bromobenzene 2 (Figure 2).
See: Figure 2: Perdeuterated Sugar Synthesis / Ph. D.
| Identifer | oai:union.ndltd.org:VTETD/oai:vtechworks.lib.vt.edu:10919/38104 |
| Date | 06 June 2008 |
| Creators | Pitzer, Kevin K. |
| Contributors | Chemistry, Hudlicky, Tomas, Tanko, James M., Gibson, Harry W., Merola, Joseph S., White, Robert H. |
| Publisher | Virginia Tech |
| Source Sets | Virginia Tech Theses and Dissertation |
| Language | English |
| Detected Language | English |
| Type | Dissertation, Text |
| Format | x, 186 leaves, BTD, application/pdf, application/pdf |
| Rights | In Copyright, http://rightsstatements.org/vocab/InC/1.0/ |
| Relation | OCLC# 34137657, LD5655.V856_1995.P589.pdf |
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