A series of structures of light atom molecules is presented. The molecules, in the main, are physiologically active or potentially active. The molecules have been divided into five broad categories. Their structure and properties are discussed. Section 1 presents some organic natural products largely isolated during the chemotaxonomic investigation of coastal marine organisms from New Zealand and Australian waters including the first porphyrin isolated from a sponge. Also presented are the structures of an isostegane and an intermediate in the synthesis of potentially odoriferous compounds. Section 2 presents compounds related to the drug amsacrine m-AMSA, of known chemotherapeutic use and other compounds produced in the study of chemotherapeutic agents, some as templates for elaboration into bis- and tris- intercalators. Section 3 presents anthraquinone derivatives related to the synthesis of compounds of known chemotherapeutic activity. One of these is a stable ozonide. Section 4 presents the study of 4, 4'-bipyridinium cations, compounds related to paraquat and exhibiting interesting electrical properties. Section 5 presents two compounds related to the study of colchicine, the most commonly used drug in the treatment of gout and a compound of other biological interest. One is an active analog the other is an intermediate in the regiocontrolled synthesis of colchicine itself.
| Identifer | oai:union.ndltd.org:ADTP/275266 |
| Date | January 1989 |
| Creators | Buckleton, John |
| Publisher | ResearchSpace@Auckland |
| Source Sets | Australiasian Digital Theses Program |
| Language | English |
| Detected Language | English |
| Rights | Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated., http://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm, Copyright: The author |
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