The role of metals in biological processes has been discussed with particular emphasis on the importance of chelation. Furst has suggested that many anticancer drugs may owe their activity to their chelating properties. A number of new amidoximes and hydroxylamine have been made from the appropriate imidoyl chloride and a hydroxylaqine. The spectral and chelating properties of these compounds are discussed. All the compounds have been submitted to the anticancer screening programme of the National Cancer Institute. The results available so far are presented and indicate that the compounds are toxic but inactive against experimental tumours. Sodium sulphide reduces a-phenyl-o-nitro-cinnamonitrile (106) to 2-amino-3-phenylquinoline-1-oxide (107) in good yield. Extension of the reduction to other o-nitrocinnamonitriles gives very poor results. The spectral properties, configurations and conformations of the o-nitrocinnamonitriles are discussed. The 12-aminoquinoline-1-oxide group is shown to form solid metal complexes. That from 2-amino-3-phenylquinoline-1-oxide (107) with nickel has been prepared. Antitumour screening results are presented for several 2-aminoquinoline derivatives. None of these compounds appears to be active.
| Identifer | oai:union.ndltd.org:ADTP/274310 |
| Date | January 1971 |
| Creators | Dean, Ian Christopher |
| Publisher | ResearchSpace@Auckland |
| Source Sets | Australiasian Digital Theses Program |
| Language | English |
| Detected Language | English |
| Rights | Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated., http://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm, Copyright: The author |
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