Chick embryo fibroblasts and rat kidney cells infected in vitro with Rous Sarcoma viruses were treated with 3-deazaguanine (3-DG). The findings revealed that 3-DG inhibited virus-induced cellular transformation. Degree of inhibition is dependent on concentration and frequency of media change. 3-DG at the concentrations tested will not reverse transformed cells to the untransformed state and does not have marked effect on replication of viruses. Upon removal of 3-DG, its effect was shown to be reversible. Cell growth was generally retarded in medium containing 3-DG. When xanthosine and inosine were added to the medium, cell growth was unaffected, but it increased in guanosine.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc504461 |
| Date | 12 1900 |
| Creators | Fadare, Samuel O. |
| Contributors | Chen, Young C., Hatten, Betty A., Vela, G. Roland, 1927- |
| Publisher | North Texas State University |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | v, 55 leaves: ill., Text |
| Rights | Public, Fadare, Samuel O., Copyright, Copyright is held by the author, unless otherwise noted. All rights reserved. |
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