Return to search

Synthesis of Substituted Pyrimidines and Pyridines as Ligands to the 5-HT7 Receptor

Of the seven existing classes of serotonin receptors, the 5-HT7 receptors (5-HT7Rs) are the most recently discovered. Abundance of 5-HT7 in the central nervous system is suggestive of the receptor’s role in several physiological and pathophysiological functions. Existing research has afforded a number of compounds exhibiting specific affinity to the receptor. These selective ligands can provide structural information about the receptor and can serve as the foundation for pharmacological profiling . This thesis describes the synthesis of substituted pyrimidines and pyridines for affinity to the 5-HT7 receptor. Organometallic species are the cornerstone for sev-eral of the synthetic pathways.

Identiferoai:union.ndltd.org:GEORGIA/oai:digitalarchive.gsu.edu:chemistry_theses-1028
Date22 April 2010
CreatorsBlake, Ava L.
PublisherDigital Archive @ GSU
Source SetsGeorgia State University
Detected LanguageEnglish
Typetext
Formatapplication/pdf
SourceChemistry Theses

Page generated in 0.0018 seconds