In this thesis, we are concerned with the molecular biology processes of ionising radiation (IR) damage and its repair. In particular, we develop a mechanistic model of high dose irradiation damage to DNA in mammalian cells by considering a population of cells structured by the number of double strand breaks and mis-repairs. This framework allows us to construct a mechanistic explanation for the Linear-Quadratic (LQ) formalism. Other contributions of this thesis are a model of ataxia telangiectasia mutated (ATM) dynamics in DNA damage repair, and a discussion of bistability, an important ingredient in the construction of a general theory of non-targeted radiation effects.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:605973 |
| Date | January 2014 |
| Creators | Siam, Fuaada Mohd |
| Publisher | University of Strathclyde |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=23162 |
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