Chapter one contains a brief resume of the recent literature reports concerning the Dotz benzannulation reaction and a short review on the current known reactivity and use of vinylidene complexes. Chapter two describes the Dotz benzannulation reaction, regiochemically and mechanistically. The annulation reaction was applied to the synthesis of the steroid, taxodione. The annulation is also further applied to the synthesis of tricyclic systems. The tricycles formation being via a tandem annulationMitsunobu cyclisation process. The tricyclic systems potentially lead to the formation of aflotoxin Bl. Chapter two also describes the Dotz cyclisation reaction, its origin and mechanistic understanding. The cyclisation reaction was applied to the novel homochiral synthesis of (R, Z)-5-(I-decenyl)dihydro- 2(3H)-furanone and to the synthesis of (+/-)-muricatacin. Chapter three describes the experimental procedures used.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:629434 |
| Date | January 1993 |
| Creators | Ricketts, Dean C. |
| Publisher | University of Manchester |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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