A strain difference was observed in juvenile OD plasticity between C57BL/6J and C57BL/6JOlaHsd mice whereby open eye 'homeostatic' potentiation was completely absent in the C57BL/6JOlaHsd strain. This was accompanied by an absence of dark exposure induced synaptic scaling as measured <italic>ex vivo.</italic> In contrast in adulthood both strains showed comparable open eye potentiation, suggesting a mechanistic difference between juvenile and adult plasticity. Preliminary data suggests that while juvenile open eye potentiation is homeostatic, in adulthood it may be more LTP like and dependent upon CaMKII autophosphorylation.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:585115 |
| Date | January 2011 |
| Creators | Ranson, Adam |
| Publisher | Cardiff University |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://orca.cf.ac.uk/54216/ |
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