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Computational modelling and molecular dynamics simulations of ligand-gated ion channels

Torpedo AChR structure was used to make models of other LGICs. Coarse-grain MD allowed the identification of residues in the TM domain interacting with the lipid-bilayer. Born energy profiles through LGIC pores reveal that the EC domain plays a key role in ion selectivity.

Identiferoai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:437382
Date January 2006
CreatorsAmiri, Shiva
ContributorsSansom, Mark S.
PublisherUniversity of Oxford
Source SetsEthos UK
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation
Sourcehttp://ora.ox.ac.uk/objects/uuid:119c7ccb-e7b2-4da1-a137-40c3289c3ad8

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