DNA topoisomerases are vital enzymes for major cellular processes like replication, transcription, and chromosome segregation. They play an essential role in solving DNA topological problems by catalysing the passage of DNA strands through each other via introducing transient single or double strand breaks. Type IIA DNA topoisomerases members introduce double strand breaks via an ATP-dependent strand passage reaction. This study aimed to investigate the roles of topo Ila and topo Iip in zebrafish development.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:493231 |
| Date | January 2008 |
| Creators | Azrak, Sami |
| Publisher | University of Newcastle Upon Tyne |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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