Daunorubicin (DNR) and its C-14 hydroxylaled derivative doxorubicin (DXR) a are the most widely used anthracyclines as anti-tumour agents. DNR and DXR are produced by the soil bacteria Streptomyces peucetius through a biosynthetic pathway that employs a type II polyketide synthase (PKS). Type II PKSs consist of several discrete, monofunctional proteins that form a dissociable complex. Studies on enzyme complex formation and substrate channelling are essential for a better understanding of metabolism and could lead to the generation of novel compounds by 'combinatorial' biosynthesis.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:500311 |
| Date | January 2008 |
| Creators | Castaldo, Gaetano |
| Publisher | University College London (University of London) |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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