Transcription by RNA polymerase 1 (Pol-1) is the main driving force behind ribosome biogensis, a fundamental cellular process that requires the coordinated transcription of all three nuclear polymerases. Increased Pol-1 transcription, and the concurrent increase in ribosome biogensis has been linked to the high rates of proliferation in many cancers. The ellipticine family contains a number of potent anticancer therapeutic agents with some having progressed to stage 1 and II clinical trial; however the mechanism by which these compounds works remain unclear.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:598029 |
| Date | January 2013 |
| Creators | Andrews, William John |
| Publisher | Queen's University Belfast |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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