Ion channels are instrumental in the regulated control of insulin secretion from the pancreatic islets. We therefore investigated the role of a novel potassium (K+) channel, TALK-1, In the endocrine pancreas. TALK-1 is a member of the twin-pore potassium (K2P) channel family, which are characterised by their unique dual pore domains and background conductance activity that Is active across the physiological range of membrane potentials. Four splice variants of human TALK-1 have previously been identified. We found that only one variant; the equivalent of human TALK-1 b is expressed in the rodent. RT-PCR and quantitative RT-PCR data revealed that TALK-1 has a limited expression profile and is most highly expressed in the islets of Langerhans in rodent and human tissues.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:495049 |
| Date | January 2008 |
| Creators | Weston, Ria V. |
| Publisher | University of Manchester |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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