Previous studies in the lab have shown that anterior-most floor plate cells undergo a change in fate in response to BMP-Tbx2 mediated signalling and give rise to ventral midline hypothalamic cells. In this study I have further characterised the ventral midline of the hypothalamus in the E4-E7 chick embryo. I demonstrate that the hypothalamic ventral midline is a complex structure comprised of distinct regions along its anterior-posterior axis. Fate-mapping studies demonstrate unequivocally that presumptive hypothalamic floor plate cells give rise to recognisable parts of the hypothalamus, In particular to the retrochiasmic, tubero-infundibular and mammillary regions and to distinct morphological structures, including the infundibulum and mammillary pouch.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:489393 |
| Date | January 2008 |
| Creators | Pearson, Caroline Alayne |
| Publisher | University of Sheffield |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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