The Cvt pathway is an unusual process which transports the two hydrolases aminopeptidase I (Apel) and a-mannosidase I (Amsl) from the cytoplasm directly to the vacuole. So far it has only been described in S. cerevisiae and closely related budding yeasts. Most of the components needed for the Cvt pathway, the Atg proteins. are also required for the autophagy pathway, a degradative system which delivers cytoplasmic constituents to the vacuole in a non-specific manner, induced under conditions such as nutrient starvation. Genes involved in these two pathways play a wide variety of roles in diseases such as cancer, cardiomyopathy, Huntington's and Parkinson's disease as well as the removal of intracellular pathogens and ageing.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:494934 |
| Date | January 2009 |
| Creators | Lakhani, Ronak |
| Publisher | University of Sussex |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
Page generated in 0.0014 seconds