Structural maintenance of chromosome (Smc) complexes have key functions in chromosome formation and segregation. Eukaryotes possess three essential Smc complexes: cohesin (Smc 1/3) which facilitates sister chromatid cohesion, condensin (Smc2/4), which facilitates chromosome condensation and segregation and Smc5/6, the less well-understood third complex. The Smc5/6 heterodimer interacts with the non-Smc proteins Nse1 to Nse6 to form a functional complex, implicated in DNA repair by homologous recombination (HR) and the segregation of repetitive DNA such as ribosomal DNA repeats. Hypomorphic complex mutants are HR defective and loss of Smc5/6 complex functions results in global chromosome fragmentation and missegregation.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:494937 |
| Date | January 2009 |
| Creators | Irmisch, Anja |
| Publisher | University of Sussex |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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