In the quest to master ocular surface regeneration, one must isolate the stem cells at the limbus and understand them. The stem cell niche is a concept that-was first described in 1978 and subsequently gained interest and became widely accepted. The work presented in Chapter 2 sought to characterize the stem cell niche at the ocular surface, and in doing so led to further understanding of stem cells at the limbus. In Chapter 3 the sampling of infant tissue provided further insight into the niche at that age group. In Chapter 4, Desmoglein 3 was hypothesized to be a negative stem cell marker. Finally in Chapter 5, the Amniotic Membrane was investigated as a possible surrogate stem cell niche. The stem cells at the limbus have not been isolated yet, but hopefully we are one step closer to mastering ocular surface reconstruction.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:580161 |
| Date | January 2011 |
| Creators | Yeung, Aaron Ming Hon |
| Publisher | University of Nottingham |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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