Three attempts at developing a radioimmunoassay for prostaglandin E were made. Two of these attempts resulted in the production of anti-sera directed mainly to prostaglandin B. The third attempt was designed to produce anti-sera specfic to prostaglandin F, a prostaglandin readily formed from prostaglandin E by reduction with sodium borohydride. The influence of age, sex and hormonal state have been studied with reference to the reduction of prostaglandin E to prostaglandin F by the enzyme systems present in sheep blood and liver samples from chicken, rabbit and guinea-pig. Ovarian steroid hormones have been found to influence the enzyme activity and preliminary evidence would suggest a link between these hormones and prostaglandin metabolism.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:652362 |
| Date | January 1977 |
| Creators | Hensby, C. N. |
| Publisher | University of Edinburgh |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://hdl.handle.net/1842/17514 |
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