Proteinase-activated receptors (PARs) are a novel family of G-protein coupled receptors (GPCRs) that mediate many of the diverse biological effects of proteinases on target cells. N-linked glycosylation is a common post-translational modification in the GPCR superfamily that enables the cell to regulate protein function without recourse to the genome. Previous pharmacological studies have found that activation of hPAR-2 by mast cell tryptase can be regulated by receptor N-terminal glycosylation. However, the role of N-linked glycosylation in regulating the expression and function of other PARs is not known.
Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:494884 |
Date | January 2008 |
Creators | Xiao, Yu Pei |
Contributors | Compton, Steven J. ; Morice, Alyn H. |
Publisher | University of Hull |
Source Sets | Ethos UK |
Detected Language | English |
Type | Electronic Thesis or Dissertation |
Source | http://hydra.hull.ac.uk/resources/hull:1695 |
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