Serial transplantation of bone marrow through irradiated syngeneic hosts resulted in a decline in the capacity of haematopoietic stem cells to (a) self-renew, and (b) regenerate the haematopoietic system of lethally irradiated mice. Repeated regeneration of the stem cell pool in situ following serial injections of hydroxyurea, however, did not result in any decline in stem cell function. A decreased immune responsiveness was observed in mice repopulated with serially transplanted bone marrow. An attempt was made to detect protein-synthetic errors in reticulocytes descended from serially transferred stem cells by measuring the heat-labile fraction of glucose-6-phosphate dehydrogenase. No increase in altered enzyme was observed.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:661406 |
| Date | January 1979 |
| Creators | Ross, Elizabeth |
| Publisher | University of Edinburgh |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://hdl.handle.net/1842/14329 |
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