In an attempt to define the role of intravascular coagulation in the pathogenesis of pre-eclampsia, a prospective series of normal primigravidae was studied through pregnancy and the puerperium. A battery of tests of coagulation and fibrinolysis was applied to maternal and cord venous blood, normal pregnancy being oompared with pregnancy preceding pre-eclampsia. A group of established proteinuric pre-eclamptics was also studied. The results failed to implicate typical major D.I.C. even in established pre-eclampsia, although a subtle low grade D.I.C. may be active in the disease. Evidence has been presented of intravascular coagulation localised to the kidneys in the established condition, and the significance of the changes found in this study are discussed in relation to the syndrome of pre-eclampsia.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:452005 |
| Date | January 1975 |
| Creators | Condie, R. G. |
| Publisher | University of Aberdeen |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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