Wnt signalling is required during cardiogenesis for both specification of heart tissue and the morphogenetic movements necessary to form the heart. Canonical signalling is required mid gastrula to restrict the size of the cardiac field whilst Wnt 11 mediated non-canonical signalling is required for cardiac induction. Wnt 11R, which is expressed later, is also thought to signal through the non-canonical pathway to promote heart morphogenesis. Xfz7is expressed during gastrulation in the mesodermal cells fated to become heart. Expression Is maintained in the primary heart field as the dorsolateral mesoderm migrates to the ventral midline. We have used loss of function analysis to determine the role of Xfz7 during heart development. Morpholino mediated knock down of Xfz7 gives a heartless phenotype similar to that of Wnt 11 morpholino.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:502217 |
| Date | January 2009 |
| Creators | Mulvaney, Joanna Frances |
| Publisher | University of East Anglia |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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