The complex polysaccharide, heparan sulfate (HS), regulates airway development by controlling cell-cell and cell-matrix communication via interactions with a vast number of proteins e.g., growth factors. Loss of HS biosynthetic enzymes in Drosophila and mice illustrates the requirement for HS in airway morphogenesis and results in a major disruption in airway branching, and in the mouse, neonatal death. However, knowledge of HS structure within the lung is limited. HS antibodies produced by 'phage display provide a new tool for analysing HS in situ and have allowed specific HS structures to be probed in the lung.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:494166 |
| Date | January 2008 |
| Creators | Thompson, Sophie Marie |
| Publisher | University of Liverpool |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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