Physiologically-based pharmacokinetic (PBPK) modelling is a computational technique which includes the anatomy and physiology of the study species (species-specific information), as well as the physicochemical properties of the study compound (compound-specific informafion). This data-rich situation confers many advantages on drug development and discovery, especially in the areas of extrapolation between species, route IS of administration and doses. However, it remains under-used in drug research. This thesis examines the applications of PBPK modelling in three different scenarios, in the light of recent developments in this field, in order to support its wider use in drug research in both preclinical and clinical areas.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:492740 |
| Date | January 2008 |
| Creators | Rodrigues, Clare Louise |
| Publisher | University of Manchester |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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