The goal of most population pharmacokinetic and pharmacodynamic analyses is to develop a model that adequately describes the available data and that can be used for predictive purposes. The assessment of covariates is of utmost importance to enhance predictive performance and ultimately to design rational dosing regimens. The increasing use of pharmacogenetics has opened up a whole new array of covariates that can potentially explain the observed between subject variability. In addition, the lack of information regarding drug therapy in special populations such as paediatrics needs to be addressed. The aims of this thesis were therefore to assess the impact of pharmacogenetics on the pharmacokinetics and/or pharmacodynamics of test compounds and to assess ways of including this covariate information into models. Furthermore, to develop models that can explain the differences between adults and paediatrics in order to develop rational dosing guidelines in the paediatric population.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:493911 |
| Date | January 2008 |
| Creators | Matthews, Ivan Thomas |
| Publisher | University of Manchester |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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