Nitric oxide (NO) is involved in numerous biological processes including cancer, where this small diatomic radical can exert both pro- and anti-cancer effects. Two series of novel NO-donors were synthesised in this work, the first representing an extension to the S-nitrosothiols (RSNO) class, with the second utilising the popular 1,2,5-oxadiazole-2-oxide (furoxan) functionality. The oxathiazolylium-5-olates 39a, 39f, 39h-D, were successfully made via improved seven-step synthesis whilst a series of combretastatin-like furoxans 144a-c (NO-hybrids) were generated in a one-pot reaction. All compounds; including byproducts from failed alternative synthetic routes, had their cytotoxic activity evaluated. From this study NO-hybrid 144c showed the most promising biological profile when tested against eight different ovarian cancer cell lines.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:699674 |
| Date | January 2012 |
| Creators | Richardson, Monica Eilertsen |
| Publisher | Keele University |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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