Thromboxane A2 (TXA2) and ADP are both major positive feedback mediators of platelet activation and act through G-protein coupled receptors (GPCRs) on the platelet surface. Aspirin and clopidogrel, two of the main drugs used in the prevention of acute coronary syndromes, function by blocking the actions of these two agonists at their receptors. Since aspirin and clopidogrel have been shown to be more effective when administered together rather than alone, the study of potential cross-talk between TXA2 and ADP receptors (TP and P2Y) is important in improving understanding of the combined mechanism of action of these two drugs.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:492443 |
| Date | January 2008 |
| Creators | Barton, Johanna F. |
| Publisher | University of Bristol |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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