Warfarin is the most widely used oral anticoagulant for the prevention and treatment of various cardiovascular diseases. However, its complications represent an important clinical problem. The drug has a very low therapeutic index and there is significant interpatient and inter-iscmer variability in both pharmacokinetics and pharmacodynamics; these are affected by a large number of genetic and non-genetic factors. Genetic variation in CYP2C9 and VKORCl has been most extensively studied in relation to warfarin dose requirements.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:501741 |
| Date | January 2009 |
| Creators | Al-Zubiedi, Sameh A. |
| Publisher | University of Liverpool |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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