is postulated that dynorphin inhibits the cocaine-induced increase in striatal dopamine levels, that may contribute to dynorphin's ability to prevent cocaine induced conditioned place preference and to attenuate an increase in locomotor activity. In this thesis interactions between dynorphin and the dopaminergic system in cocaine addiction have been addressed using preprodynorphin gene knockout mice treated with a chronic "binge" cocaine protocol.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:493210 |
| Date | January 2008 |
| Creators | Yoo, Ji Hoon |
| Publisher | University of Surrey |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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