Eosinophils are characteristic infiltrating cells in asthmatic airways and may contribute to allergic and inflammatory diseases pathology through the ability of their products to produce chronic inflammatory and remodelling processes. One focus of efforts to define new therapeutic targets for chronic inflammatory diseases has been the study of mechanisms through which eosinophils are recruited to tissues and become activated, leading to secretion of reactive oxygen species, inflammatory mediators, cationic proteins and cytokines. The signalling pathways responsible for evoking migratory and secretory response in human eosinophils are incompletely understood.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:505655 |
| Date | January 2008 |
| Creators | Hasan, Anwar Matar |
| Publisher | Keele University |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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