High-mobility group box 1 protein (HMGBl) is a nuclear component, but extracellularly it serves as a signaling molecule involved in acute and chronic inflammation, for example in sepsis and arthritis. The identification of HMGBl inhibitors is therefore of significant experimental and clinical interest. We show that glycyrrhizin, a natural anti-inflammatory and antiviral triterpene in clinical use, inhibits HMGBl chemoattractant and mitogenic activities, and has a weak inhibitory effect on its intranuclear DNA binding function.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:489904 |
| Date | January 2008 |
| Creators | Mollica, Luca |
| Publisher | Open University |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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