Temporal rhythms are an important aspect of physiological and behavioural systems. A picture is now developing indicating the importance of biological rhythms in both health and disease. This is particularly evident in inflammatory diseases, such as rheumatoid arthritis (RA), which demonstrates a temporal aspect to disease severity. hi order to fully exploit the potential of timing pharmacological drug treatment to endogenous rhythms (chronotherapy), a greater understanding of temporal control of mediators involved in diseases, as well as the kinetics of the therapeutics, is required.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:494669 |
| Date | January 2007 |
| Creators | McMaster, Andrew |
| Publisher | University of Manchester |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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