Cardiac surgery with cardiopulmonary bypass (CPB) can trigger systemic inflammatory response syndrome (SIRS) in patients. Pro-inflammatory cytokines lL-6 and IL-8 are reported as particular markers in blood of the inflammatory •espouse to CPB. It would be useful to measure the inflammatory response in the surgical theatre in real/near real time to improve the effectiveness and timings for interventions which may counteract any undesirable inflammatory response. Currently, Enzyme Linked Immunosorbent Assays (ELISAs) and similar systems are used in the central laboratory to measure inflammatory markers however they do not provide results within the appropriate timescale for rapid intervention. Consequently other approaches to assay provision at point of care must be considered. This thesis is concerned with the design, fabrication and characterisation of a prototype, electrochemical, lateral flow system opening a new approach to rapid, point of care (POC), quantitative monitoring of inflammatory markers.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:501682 |
| Date | January 2008 |
| Creators | Gray, Louise Elizabeth |
| Publisher | University of Strathclyde |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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