This thesis describes a randomized, double-blind, placebo-controlled, clinical trial investigating the effect of a multiple micronutrient supplement in patients with stable chronic heart failure. Seventy-nine patients with chronic stable heart failure were recruited and randomized to treatment with a multiple micronutrient supplement or placebo. The primary end-point of the study was left ventricular ejection fraction (LVEF), assessed using cardiovascular magnetic resonance imaging or 3·dimensional echocardiography. The secondary end·points were quality of life (assessed using the Minnesota Living With Heart Failure Questionnaire), physical functioning (assessed using six-minute walk test distance), blood levels of N·terminal prohormone of brain natriuretic peptide, blood levels of Creactive protein, blood • levels of pro· and anti-inflammatory cytokines (tumour necrosis factor alpha. interleukin·6 and mterleukin-10) and urinary levels of a marker of oxidative stress (8· iso·prostagtandin F2 alpha). All end-points were assessed at baseline and after 12 months of treatment with the study medication . Compliance with the study med ication was assessed by measuring blood levels of a number of micro nutrients contained within the multiple micronutrient supplement. There was evidence of good compliance with the study medication in nearly all subjects. With respect to the primary end-point , complete follow-up data were available for 68 subjects (35 patients in th~ placebo group and 33 patients in the multiple micronutrient supplement group). There was no evidence of a significant effect of multiple micronutrient supplementation on LVEF In addition, there was no evidence of a significant effect of multiple micronutrient supplementation on any of the secondary end·points. This study, therefore, provides no evidence to support the routine treatment with a multiple micronutrient supplement of such patients with chronic stable heart failure.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:602502 |
| Date | January 2013 |
| Creators | McKeag, Nicholas Adam |
| Publisher | Queen's University Belfast |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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