The role of the plasma membrane calcium ATPase (PMCA), a calcium extruding enzyme, in cardiac physiology is not yet entirely clear. Two isoforms of PMCA, PMCAl and 4, are expressed in the myocardium. In the heart PMCA had originally been thought to play a rather minor role in cardiac relaxation. However, our group has suggested a new function for PMCA4b as a modulator of signal transduction pathways through its interaction with neuronal nitric oxide synthase (nNOS) in a cellular model; however, the role of the PMCA4-nN0S complex in the heart is still unclear. In addition, the differential role of the isoforms 1 and 4 remained enigmatic. The aim of the current study was to investigate the molecular mechanisms by which PMCA isoforms (1 and 4) modulate cardiac contractility.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:493674 |
| Date | January 2008 |
| Creators | Mohamed, Tamer M. A. |
| Publisher | University of Manchester |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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