CHF is a complex disease that results in the remodelling of the heart at every level, from the gross anatomy down to the levels of the ion channel resulting in aberrant signalling and contractile dysfunction. The QT interval of the cardiac ECG is frequently increased in heart failure, suggesting ion channel remodelling which has proarrhythmic consequences. One of the aims of this study was to determine the changes that occur from the in vivo level, down to the level of the ion channel that may contribute to arrhythmogenesis.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:493676 |
| Date | January 2008 |
| Creators | Diffley, Leonie |
| Publisher | University of Manchester |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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