Jype 2 diabetes (2DM) is linked with cognitive deficits in aged human patients with poor diabetic control. Conflicting evidence exists from studies Into cognitive deficits using streptozotocin (ST Z) induced and spontaneous diabetic models; furthermore, the mechanism for cognitive deficits is unclear. The Goto-Kakizaki (GK) rat, a spontaneous non-obese model of 2DM, was selected to isolate the effects of prolonged hyperglycaemia on brains of aged GK rats using behavioural tasks, electrophysiology and immunochemistry, compared with age-matched Wistar control rats.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:495650 |
| Date | January 2008 |
| Creators | Brierley, Rachel Claire Mary |
| Publisher | University of Bristol |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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