Epigenetic unmasking, either by pharmacological inhibition or direct gene targeting, has been utilised to identify novel tumour suppressor genes that are silenced in association with inappropriate CpG island (CGI) methylation in various types of cancer. In this study, an epigenetic unmasking strategy was developed to identify novel genes that are silenced in association with inappropriate, CGI methylation in pituitary tumours.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:493649 |
| Date | January 2009 |
| Creators | Dudley, Kevin |
| Publisher | Keele University |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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