The data presented shows that IL-1beta has a biphasic effect on PTC TGF-beta signalling, with early NF-kappaB-mediated inhibition and delayed sensitization via an autocrine IL-6 loop, and possibly also via an autocrine IL-6 loop, and possibly also via a switch from NF Kappa B p52/p50 heterodimer to p50/p50 homodimer formation. Secondly, the data indicates that BMP-7 prevents TGF-beta1-mediated loss of the transcriptional repressor SnoN and hence specifically limits Smad3 DNA binding, altering the balance of transcriptional responses to TGF-beta1 in PTC.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:585055 |
| Date | January 2010 |
| Creators | Luo, Dong-Dong |
| Publisher | Cardiff University |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://orca.cf.ac.uk/55488/ |
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