The cytokines, a family of poly-peptides that are central to the coordination of the inflammatory response, exert significant influence on the progression of acute cerebral ischaemic injury, or 'stroke'. Evidence has accumulated for a similarly significant role for cytokines in physical repair and neurological recovery after stroke, via actions within the injured central nervous system and through mediation of peripheral inflammation. This thesis addresses the spatio-temporal expression profile of cytokines in response to cerebral ischaemia in the rat, and the influence of elevated peripheral cytokine concentration on physical repair of the CNS.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:633022 |
| Date | January 2006 |
| Creators | Stock, Christopher John |
| Publisher | University of Manchester |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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