The commensal bacterium Enterococcus faecalis has emerged as an opportunistic pathogen capable of causing a range of infections. Little is known about the role and regulation of excreted proteins in E. faecalis virulence. Cytolysin is regulated via a specific density regulation mechanism and expression of GelE and SprE is dependent on the quorum sensing regulatory system FsrABCD. Fsr is predicted to be a global regulator of protein synthesis but it is not known whether there are multiple hierarchical regulators that modulate Fsr expression, as seen in the homologous Agr system in Staphylococcus aureus. This study sought lo investigate the variability and regulation of excreted proteins in the lab strains OGIRF and JH2-2 and in a set of diverse clinical isolates.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:494131 |
| Date | January 2008 |
| Creators | Walker, Rachel Georgina |
| Publisher | University of Liverpool |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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