Histone deacetylase inhibitors have great potential as chemotherapeutic agents both alone and in combination with other agents, however their mechanism of action is poorly understood. Studies into the effects of HDI on numerous tumour cell lines demonstrated some variation in the responses to these agents and gene expression profiling revealed that a variety of cellular processes are altered after HDI treatment.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:489440 |
| Date | January 2007 |
| Creators | Fotheringham, Susan |
| Publisher | University of Oxford |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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