This thesis concerns the synthesis and characterisation of novel bis(diketonate) titanium dihalides. The compounds synthesised during the course of this work have been evaluated as potential anti-tumour agents. Chapter 1 comprises a brief review of the literature on of the role of titanium in transition metal anti-tumour agents as well comments on the industrial uses of the bis(diketonate) ligand. Chapter 2 compares the novel crystal structures of la 1,3-p-diketonatc molecules as well as the synthesis and characterisation of three novel bis(diketonatc) titanium isopropoxidc compounds. Chapter 3 concerns the synthesis and characterisation of 12 novel bis(diketonate) titanium dichlorides along with 8 novel crystal structures. In addition 5 novel mono(diketonate) titanium trichloridcs along with 4 novel crystal structures. Chapter 4 describes the synthesis and characterisation of 14 novel bis(dikctonate) titanium dibromides along with 8 novel crystal structures. Chapter 5 gives an account of the biological evaluation of a series of the bis(diketonate) titanium compounds including an SRB assay and DNA binding study. The SRB assay revealed one compound, 4.2, to show anti-tumour activity comparable to that of cisplatin in the A2780eis cell line. There is also a section on future work defining key features for further study. Chapter 6 represents experimental details and characterisation data for the compounds described in Chapters 1-5.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:612609 |
| Date | January 2008 |
| Creators | Mannion, James Joseph |
| Publisher | University of Leeds |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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