The evasion of apoptosis is a common feature of various malignancies and often depends on the overexpression of Bcl-2 family antiapoptotic proteins. Resistance to chemotherapy and radiotherapy is promoted because these tumour cells have a higher threshold for apoptosis-promoting signals than their normal cell counterparts. This has lead to the development of BH3 mimetic compounds that target the survival proteins of the Bcl-2 family.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:506239 |
| Date | January 2009 |
| Creators | Micha, Dimitra |
| Publisher | University of Manchester |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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