The role of ERα in hormone responsive breast cancer is well established but that of ERβ remains to be determined. In this thesis, the effects of overexpression of ERβlong have been studied in MCF7 human breast cancer cells which possess high endogenous levels of ERα . Stable overexpression of ERβlong protein (2-fold) resulted in reduced fold induction (from 2.6 to 1.8) of an ERE-CAT reporter gene with 10-8M 17β-oestradiol but enhanced fold induction (from 1.18 to 2.12) by 10-5M genistein and an increased induction (from 4.4 to 11.4) of growth with 10-4M methylparaben.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:494000 |
| Date | January 2007 |
| Creators | Pugazhendhi, Dhamayanthi |
| Publisher | University of Reading |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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