WWP1 is a ubiquitin ligase of the Nedd4-protein like family. Previous analysis in our laboratory suggested a possible relationship between WWP1 expression and breast cancer. This work attempted to characterise WWP1 expression and potential function in breast oncology. WWP1 mRNA expression was found to be up regulated mostly in ER+ breast tumour cell lines compared with non tumourigenic cell lines. In our experiments, WWP1 expression was not activated by oestrogen.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:492856 |
| Date | January 2008 |
| Creators | Nguyen Huu, Ngoc-Sa |
| Publisher | University of Manchester |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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