This study examined whether the transforming growth factor-β (TGF-P) signalling pathway switches from a tumour suppressing to a pro-metastatic function during the progression of human squamous cell carcinoma (SCC). Preliminary studies aimed to determine whether the HaCaT model of human SCC together with the in vivo technique of floor of the mouth (FOM) transplantation of cells to athymic mice provided a good model of human SCC. Following FOM inoculation, HaCaT was non-tumorigenic while the remaining cell lines displayed an increasingly aggressive phenotype in vivo confirming that the HaCaT model and FOM inoculation technique were suitable for the study of SCC progression.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:503878 |
| Date | January 2009 |
| Creators | Ganapathy, Anuradha |
| Publisher | University of Bristol |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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